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Some of the Factors Involved in Male Infertility: A Prospective Review

Authors Babakhanzadeh E, Nazari M, Ghasemifar S, Khodadadian A

Received 4 December 2019

Accepted for publication 23 January 2020

Published 5 February 2020 Volume 2020:13 Pages 29—41


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser

Emad Babakhanzadeh,1,2 Majid Nazari,1 Sina Ghasemifar,1 Ali Khodadadian1

1Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; 2Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Correspondence: Ali Khodadadian
Genetic Department, Clinical and Research Centre for Infertility, Bou-Ali Avenue, Safayeh, Yazd, Iran
Tel +98 351 8247085
Fax +98 351 8247087

Abstract: Infertility is defined as the inability of couples to have a baby after one year of regular unprotected intercourse, affecting 10 to 15% of couples. According to the latest WHO statistics, approximately 50– 80 million people worldwide sufer from infertility, and male factors are responsible for approximately 20– 30% of all infertility cases. The diagnosis of infertility in men is mainly based on semen analysis. The main parameters of semen include: concentration, appearance and motility of sperm. Causes of infertility in men include a variety of things including hormonal disorders, physical problems, lifestyle problems, psychological issues, sex problems, chromosomal abnormalities and single-gene defects. Despite numerous efforts by researchers to identify the underlying causes of male infertility, about 70% of cases remain unknown. These statistics show a lack of understanding of the mechanisms involved in male infertility. This article focuses on the histology of testicular tissue samples, the male reproductive structure, factors affecting male infertility, strategies available to find genes involved in infertility, existing therapeutic methods for male infertility, and sperm recovery in infertile men.

Keywords: male infertility, spermatogenesis, azoospermia, non-obstructive azoospermia

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