Back to Journals » International Journal of Nanomedicine » Volume 15

Smart Hydrogels – Synthetic Stimuli-Responsive Antitumor Drug Release Systems

Authors Kasiński A, Zielińska-Pisklak M, Oledzka E, Sobczak M

Received 9 February 2020

Accepted for publication 28 March 2020

Published 25 June 2020 Volume 2020:15 Pages 4541—4572

DOI https://doi.org/10.2147/IJN.S248987

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Thomas Webster


Adam Kasiński, Monika Zielińska-Pisklak, Ewa Oledzka, Marcin Sobczak

Department of Biomaterials Chemistry, Chair of Analytical Chemistry and Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, Warsaw 02-097, Poland

Correspondence: Marcin Sobczak Tel +48-22-572-07-55
Email marcin.sobczak@wp.pl

Abstract: Among modern drug formulations, stimuli-responsive hydrogels also called “smart hydrogels” deserve a special attention. The basic feature of this system is the ability to change their mechanical properties, swelling ability, hydrophilicity, bioactive molecules permeability, etc., influenced by various stimuli, such as temperature, pH, electromagnetic radiation, magnetic field and biological factors. Therefore, stimuli-responsive matrices can be potentially used in tissue engineering, cell cultures and technology of innovative drug delivery systems (DDSs), releasing the active substances under the control of internal or external stimuli. Moreover, smart hydrogels can be used as injectable DDSs, due to gel–sol transition connected with in situ cross-linking process. Innovative smart hydrogel DDSs can be utilized as matrices for targeted therapy, which enhances the effectiveness of tumor chemotherapy and subsequently limits systemic toxicity. External stimulus sensitivity allows remote control over the drug release profile and gel formation. On the other hand, internal factors provide drg accumulation in tumor tissue and reduce the concentration of active drug form in healthy tissue. In this report, we summarise the basic knowledge and chemical strategies for the synthetic smart hydrogel DDSs applied in antitumor therapy.

Keywords: smart hydrogels, stimuli-responsive hydrogels, controlled release, drug delivery systems, anticancer drug delivery systems

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]