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Sleep disturbance in mental health problems and neurodegenerative disease

Authors Anderson KN, Bradley AJ

Received 18 January 2013

Accepted for publication 16 February 2013

Published 31 May 2013 Volume 2013:5 Pages 61—75


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Kirstie N Anderson1 Andrew J Bradley2,3

1Department of Neurology, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle Upon Tyne, UK; 2Eli Lilly and Company Limited, Lilly House, Basingstoke, UK; 3Institute of Neuroscience, Newcastle University, Newcastle Upon Tyne, UK

Abstract: Sleep has been described as being of the brain, by the brain, and for the brain. This fundamental neurobiological behavior is controlled by homeostatic and circadian (24-hour) processes and is vital for normal brain function. This review will outline the normal sleep–wake cycle, the changes that occur during aging, and the specific patterns of sleep disturbance that occur in association with both mental health disorders and neurodegenerative disorders. The role of primary sleep disorders such as insomnia, obstructive sleep apnea, and REM sleep behavior disorder as potential causes or risk factors for particular mental health or neurodegenerative problems will also be discussed.

Keywords: sleep, mental health, neurodegenerative disorders, cognition

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