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Skin rejuvenation using cosmetic products containing growth factors, cytokines, and matrikines: a review of the literature

Authors Aldag C, Nogueira Teixeira D, Leventhal PS

Received 30 June 2016

Accepted for publication 7 October 2016

Published 9 November 2016 Volume 2016:9 Pages 411—419


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Jeffrey Weinberg

Caroline Aldag,1,* Diana Nogueira Teixeira,1,* Phillip S Leventhal2

1Merz Pharmaceuticals GmbH, Frankfurt am Main, Germany; 24Clinics, Paris, France

*These authors contributed equally to this work

Skin aging is primarily due to alterations in the dermal extracellular matrix, especially a decrease in collagen I content, fragmentation of collagen fibrils, and accumulation of amorphous elastin material, also known as elastosis. Growth factors and cytokines are included in several cosmetic products intended for skin rejuvenation because of their ability to promote collagen synthesis. Matrikines and matrikine-like peptides offer the advantage of growth factor-like activities but better skin penetration due to their much smaller molecular size. In this review, we summarize the commercially available products containing growth factors, cytokines, and matrikines for which there is evidence that they promote skin rejuvenation.

Keywords: cosmetics, skin, aging, growth factor, cytokine, matrikine

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