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Single-walled carbon nanotubes-ciprofloxacin nanoantibiotic: strategy to improve ciprofloxacin antibacterial activity

Authors Assali M, Zaid AN, Abdallah F, Almasri M, Khayyat R

Received 27 April 2017

Accepted for publication 20 June 2017

Published 7 September 2017 Volume 2017:12 Pages 6647—6659


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Thomas Webster

Mohyeddin Assali,1 Abdel Naser Zaid,1 Farah Abdallah,1 Motasem Almasri,2 Rasha Khayyat3

1Department of Pharmacy, Faculty of Medicine and Health Sciences, An Najah National University, Nablus, Palestine; 2Department of Biology and Biotechnology, Faculty of Science, An Najah National University, Nablus, Palestine; 3Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, An Najah National University, Nablus, Palestine

Abstract: As infectious diseases continue to be one of the greatest health challenges worldwide, the demand toward alternative agents is continuously increasing. Recent advancement in nanotechnology has expanded our ability to design and construct nanomaterials to treat bacterial infections. Carbon nanotubes are one among these nanomaterials. Herein, we describe the covalent functionalization of the single-walled carbon nanotubes (SWCNTs) with multiple molecules of ciprofloxacin. The prepared nanoantibiotics were characterized using different techniques, including transmission electron microscopy, Raman spectroscopy, and thermogravimetric analysis. The characterization of the nanoantibiotics confirmed the successful covalent functionalization of the SWCNTs with 55% of functionalization as has been observed by thermogravimetric analysis. The release profile revealed that 90% of the loaded ciprofloxacin was released within 2.5 h at pH 7.4 showing a first-order release profile with R2>0.99. Interestingly, the results of the antibacterial activity indicated that the functionalized SWCNTs have significant increase in the antibacterial activity against the three strains of bacteria – by 16-fold for Staphylococcus aureus and Pseudomonas aeruginosa and by 8-fold for Escherichia coli – in comparison to the ciprofloxacin free drug. Moreover, the synthesized nanoantibiotic showed high hemocompatibility and cytocompatibility over a wide concentration range.

Keywords: covalent functionalization, hydrophilic/hydrophobic balance, carbon nanotubes, nanoantibiotic

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