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Single and Repeated Intrapleural Ropivacaine Administration: A Plasma Concentration and Pharmacodynamics Study

Authors Chen Y, Cai Y, Ye Y, Xia Y, Papadimos TJ, Liu L, Xu X, Wang Q, Shi K, Wu Y

Received 5 December 2020

Accepted for publication 26 February 2021

Published 19 March 2021 Volume 2021:14 Pages 785—791

DOI https://doi.org/10.2147/JPR.S295913

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Jinlei Li


Yuanqing Chen,1 Yaoyao Cai,1 Yingchao Ye,1 Yun Xia,2 Thomas J Papadimos,2 Le Liu,1 Xuzhong Xu,3 Quanguang Wang,1 Kejian Shi,1 Yiquan Wu1

1Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, People’s Republic of China; 2Department of Anesthesiology, The Ohio State University Wexner Medical Center, Columbus, OH, USA; 3Private Anesthesiology Consultant, Wenzhou, People’s Republic of China

Correspondence: Kejian Shi
Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang, 325000, People’s Republic of China
Tel +86-13868889697
Email [email protected]
Yiquan Wu
Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, South Baixiang Town, Wenzhou City, Zhejiang Province, 325000, People’s Republic of China
Tel +86-13867715375
Email [email protected]

Background: Intrapleural analgesia has been increasingly recommended for postoperative analgesia after thoracic surgery. However, the analgesic effect provided by a single intrapleural administration is time limited. This study reports the efficacy and safety of repeated intrapleural 0.75% ropivacaine administration after thoracoscopic surgery.
Methods: Twenty patients were randomly divided into two groups: a single administration group receiving a single intrapleural injection of 0.75% ropivacaine 15 mL (single administration group, SA group), and a repeated administration group with an intrapleural injection of 0.75% ropivacaine 15 mL every 4h for 4 doses (repeated administration group, RA group). The primary outcomes of this study were the peak plasma concentration of ropivacaine and 24h morphine consumption. The secondary outcomes were pain score, patient satisfaction, extubation time, hospital length of stay, and adverse reactions.
Results: In SA group, the highest plasma concentration after intrapleural administration of 0.75% ropivacaine 15 mL was 1345± 364 μg/L. The highest plasma concentration in RA group after the fourth administration was 1864± 492 μg/L. The 24h morphine consumption in RA group was significantly less than that in SA group (9.0± 5.66 vs 15.9± 3.48 mg, P=0.004). The NRS scores at rest and while coughing of patients in RA group were significantly lower than those in SA group at 5, 9, 13, 17 and 24h after operation. The patients in RA group had higher satisfaction than those in SA group. There was no significant difference in postoperative adverse events, drainage tube placement days and hospital length of stay between the two groups.
Conclusion: Repeated intrapleural administration with 0.75% ropivacaine, 15 mL every 4h for 4 doses after video-assisted thoracoscopic lobectomies, can provide a more durable and more effective analgesic effect than single intrapleural administration. Repeated intrapleural administration of ropivacaine is an effective postoperative method of analgesia resulting in higher patient satisfaction. Moreover, it was also able to keep the plasma concentration of ropivacaine within a possible safe range.
Clinical Trial Registration Number: ChiCTR-IOR-17010560.

Keywords: intrapleural analgesia, ropivacaine, dosage

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