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Similar and Different Regional Homogeneity Changes Between Bipolar Disorder and Unipolar Depression: A Resting-State fMRI Study

Authors Liu P, Li Q, Zhang A, Liu Z, Sun N, Yang C, Wang Y, Zhang K

Received 12 February 2020

Accepted for publication 9 April 2020

Published 28 April 2020 Volume 2020:16 Pages 1087—1093

DOI https://doi.org/10.2147/NDT.S249489

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Professor Jun Chen


Penghong Liu,1,2 Qi Li,1,2 Aixia Zhang,1 Zhifen Liu,1 Ning Sun,1 Chunxia Yang,1 Yanfang Wang,1 Kerang Zhang1

1Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan 030001, People’s Republic of China; 2Department of Psychiatry, Shanxi Medical University, Taiyuan 030001, People’s Republic of China

Correspondence: Yanfang Wang; Kerang Zhang
Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan 030001, People’s Republic of China
Tel +86-13934556065
; +86-18834180209
Email Wangyanfang12388@163.com; atomsxmu@vip.163.com

Objective: To investigate the regional homogeneity (ReHo) between unipolar depression (UD) and bipolar disorder (BD), and to search for brain imaging markers for distinguishing UD and BD.
Methods: A total of  58 patients who met the diagnosis criteria of UD in DSM–Ⅳ, 40 patients who met the diagnosis criteria of BD in DSM-Ⅳ and 54 healthy controls (HC) completed the resting-state functional magnetic resonance (rs-fMRI) scans. The ReHo of the three groups was compared and Pearson correlation analysis was performed between the ReHo values and the clinical symptoms.
Results: (1) Significant differences were found in the right hippocampus, right parahippocampal gyrus, right Inferior orbitofrontal gyrus, right superior temporal gyrus, right inferior temporal gyrus, and right middle occipital gyrus across the three groups. (2) Compared to HC, the ReHo in the right parahippocampal gyrus in UD significantly increased. (3) When compared to HC, the ReHo in the right hippocampus in BD significantly increased. The ReHo in the right middle occipital gyrus decreased. (4) Compared to UD, BD exhibited significantly decreased ReHo in the right inferior temporal gyrus. No correlations were observed between the scores of 24-item Hamilton Depression Rating Scale (HDMD-24), Hamilton Anxiety Scale (HAMA), Young Mania Rating Scale (YMRS), and the ReHo values of altered brain regions between BD and UD.
Conclusion: The results suggest that there was a considerable difference in the ReHo of brain among UD, BD, and HCs. ReHo in the right inferior temporal gyrus showed significant differences between BD and UD that might serve as neuroimaging markers to identify BD and UD.

Keywords: bipolar depression, unipolar depression, rs-fMRI, regional homogeneity

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