Back to Journals » International Journal of Nanomedicine » Volume 8 » Issue 1

Silver nanoparticle/chitosan oligosaccharide/poly(vinyl alcohol) nanofibers as wound dressings: a preclinical study

Authors Li CW, Fu RQ, Yu CP, Li ZH, Guan HY, Hu DQ, Zhao DH, Lu LC

Received 17 July 2013

Accepted for publication 24 August 2013

Published 1 November 2013 Volume 2013:8(1) Pages 4131—4145

DOI https://doi.org/10.2147/IJN.S51679

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Chenwen Li,1,* Ruoqiu Fu,1,* Caiping Yu,1 Zhuoheng Li,1 Haiyan Guan,1 Daqiang Hu,1 Dehua Zhao,2 Laichun Lu1

1Department of Pharmacy, Institute of Surgery Research, Daping Hospital, Third Military Medical University, 2College of Pharmacy, Chongqing Medical University, Chongqing, People's Republic of China

*These authors contributed equally to this work

Abstract: In this study, a mixture of poly(vinyl alcohol) (PVA) and chitosan oligosaccharides (COS) was electrospun with silver nanoparticles (AgNPs) to produce fibrous mats for use in wound healing. The AgNPs were reduced by COS prior to electrospinning or Ag+ was reduced via ultraviolet irradiation in nanofibers. The morphologies of the PVA/COS/AgNO3 and PVA/COS-AgNP nanofibers were analyzed by scanning electron microscopy. Formation of the AgNPs was investigated by field emission transmission electron microscopy, ultraviolet-visible spectroscopy, Fourier transform infrared spectroscopy, and X-ray diffraction. We also evaluated the biocompatibility of the nanofibers, particularly their cytotoxicity to human skin fibroblasts and potential to cause primary skin irritation. The in vitro antibacterial activity and in vivo wound healing capacity of the nanofibers were also investigated. The nanofibers had a smooth surface with an average diameter of 130–192 nm. The diameters of the AgNPs were in the range of 15–22 nm. The nanofibers significantly inhibited growth of Escherichia coli and Staphylococcus aureus bacteria. PVA/COS-AgNP nanofibers accelerated the rate of wound healing over that of the control (gauze). The results of our in vitro and in vivo animal experiments suggest that PVA/COS-AgNP nanofibers should be of greater interest than PVA/COS/AgNO3 nanofibers for clinical use as a bioactive wound dressing.

Keywords:
preclinical study, wound dressing, electrospinning, silver nanoparticles, poly(vinyl alcohol), chitosan oligosaccharides

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Other article by this author:

Silver nanoparticles/chitosan oligosaccharide/poly(vinyl alcohol) nanofiber promotes wound healing by activating TGFβ1/Smad signaling pathway

Li CW, Wang Q, Li J, Hu M, Shi SJ, Li ZW, Wu GL, Cui HH, Li YY, Zhang Q, Yu XH, Lu LC

International Journal of Nanomedicine 2016, 11:373-387

Published Date: 21 January 2016

Readers of this article also read:

Birdshot uveitis: current and emerging treatment options

Menezo V, Taylor SRJ

Clinical Ophthalmology 2014, 8:73-81

Published Date: 18 December 2013

Targeted delivery of let-7a microRNA encapsulated ephrin-A1 conjugated liposomal nanoparticles inhibit tumor growth in lung cancer

Lee HY, Mohammed KA, Kaye F, Sharma P, Moudgil BM, Clapp WL, Nasreen N

International Journal of Nanomedicine 2013, 8:4481-4494

Published Date: 21 November 2013

The impact of PEGylation patterns on the in vivo biodistribution of mixed shell micelles

Gao H, Liu J, Yang C, Cheng T, Chu L, Xu H, Meng A, Fan S, Shi L, Liu J

International Journal of Nanomedicine 2013, 8:4229-4246

Published Date: 5 November 2013

Promotion of peripheral nerve regeneration of a peptide compound hydrogel scaffold

Wei GJ, Yao M, Wang YS, Zhou CW, Wan DY, Lei PZ, Wen J, Lei HW, Dong DM

International Journal of Nanomedicine 2013, 8:3217-3225

Published Date: 22 August 2013

Nanolipodendrosome-loaded glatiramer acetate and myogenic differentiation 1 as augmentation therapeutic strategy approaches in muscular dystrophy

Afzal E, Zakeri S, Keyhanvar P, Bagheri M, Mahjoubi P, Asadian M, Omoomi N, Dehqanian M, Ghalandarlaki N, Darvishmohammadi T, Farjadian F, Golvajoee MS, Afzal S, Ghaffari M, Cohan RA, Gravand A, Ardestani MS

International Journal of Nanomedicine 2013, 8:2943-2960

Published Date: 8 August 2013

Engineering of epidermis skin grafts using electrospun nanofibrous gelatin/polycaprolactone membranes

Duan H, Feng B, Guo X, Wang J, Zhao L, Zhou G, Liu W, Cao Y, Zhang WJ

International Journal of Nanomedicine 2013, 8:2077-2084

Published Date: 5 June 2013

Synthesis of talc/Fe3O4 magnetic nanocomposites using chemical co-precipitation method

Kalantari K, Bin Ahmad M, Shameli K, Khandanlou R

International Journal of Nanomedicine 2013, 8:1817-1823

Published Date: 15 May 2013

Release profile and stability evaluation of optimized chitosan/alginate nanoparticles as EGFR antisense vector

Ebrahim Azizi, Alireza Namazi, Ismaeil Haririan, et al

International Journal of Nanomedicine 2010, 5:455-461

Published Date: 29 June 2010

Clinical applications of perfluorocarbon nanoparticles for molecular imaging and targeted therapeutics

Trung D Tran, Shelton D Caruthers, Michael Hughes, John N Marsh, Tillmann Cyrus, et al

International Journal of Nanomedicine 2007, 2:515-526

Published Date: 15 January 2008