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Significant pain relief with loading dose zoledronic acid in bone metastases is only seen in patients with elevated initial serum C telopeptide (CTX)

Authors Dekoninck J, Geurs F, De Loecker R, Deprest Y

Published 28 July 2011 Volume 2011:2 Pages 13—18

DOI https://doi.org/10.2147/POR.S15391

Review by Single-blind

Peer reviewer comments 2


J Dekoninck1, F Geurs1, R De Loecker2, Y Deprest2
1Department of Medical Oncology, 2Laboratory, Regional Hospital Sint Maria, Halle, Belgium

Abstract: In symptomatic bone metastases with significant pain, refractory to standard analgesics and radiotherapy, loading dose zoledronic acid (ZA) represents a simple and nontoxic treatment to obtain significant pain relief in a very short time. Its analgesic effect is limited to patients with massive osteoclast activation with high initial serum C-telopeptide (CTX). The pain reduction is proportionally correlated with the reduction of CTX.

Keywords: bone resorption, bisphosphonates, CTX levels, VAS score
 

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