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Significant association between long non-coding RNA HOTAIR polymorphisms and cancer susceptibility: a meta-analysis

Authors Zhang J, Liu X, You L, Zhou R

Received 25 February 2016

Accepted for publication 27 April 2016

Published 1 June 2016 Volume 2016:9 Pages 3335—3343

DOI https://doi.org/10.2147/OTT.S107190

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Ram Prasad

Peer reviewer comments 2

Editor who approved publication: Dr William Cho


Jian Zhang,1 Xu Liu,2 Liang-Hao You,1 Rui-Zhi Zhou1

1Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, People’s Republic of China; 2Department of Neurology, First Affiliated Hospital of China Medical University, Shenyang, People’s Republic of China

Abstract: HOTAIR, a well-known long non-coding RNA, is involved in carcinogenesis and progression of multiple cancers. Molecular epidemiological studies suggest that HOTAIR polymorphisms may be associated with cancer susceptibility, but the results remain controversial. To derive a more precise evaluation, we performed a meta-analysis focused on the associations between HOTAIR polymorphisms and cancer risk for the first time. PubMed, Embase, China National Knowledge Infrastructure, and Wanfang databases were searched. Odds ratios (ORs) with 95% confidence interval (CI) were applied to assess the association between HOTAIR rs920778 C>T, rs4759314 A>G, rs7958904 G>C, and rs1899663 G>T polymorphisms and cancer susceptibility. Analyses were conducted to detect heterogeneity, sensitivity, and publication bias in order to measure the robustness of our findings. Overall, 13 related studies involving 7,151 patients and 8,740 control samples were analyzed. Significant associations between the HOTAIR rs920778 polymorphism and cancer risk were observed (T vs C: OR =1.33, 95% CI =1.17–1.53; TT vs TC + CC: OR =1.55, 95% CI =1.21–2.00; TC + TT vs CC: OR =1.33, 95% CI =1.11–1.59; TT vs CC: OR =2.02, 95% CI =1.31–3.10) in the total population, as well as in subgroup analyses. For rs4759314 A>G polymorphism, a similarly increased risk was found in the gastric cancer group. However, significant decreases in cancer risk were observed both in the overall population and colorectal cancer group for rs7958904 G>C polymorphism. In addition, no significant association was detected between rs1899663 G>T polymorphism and cancer susceptibility. In conclusion, our meta-analyses suggest that HOTAIR polymorphisms may be associated with the risk of cancer development.

Keywords: HOTAIR, polymorphism, cancer susceptibility

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