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Significance of Surgery in the Treatment of Colorectal Cancer Ovarian Metastases: A Retrospective Case Matching Study

Authors Xu Y, Feng Q, Chen Y, Mao Y, Zhang Z, Lv Y, Zheng P, Yu S, He G, Xu J

Received 6 October 2020

Accepted for publication 8 January 2021

Published 5 February 2021 Volume 2021:13 Pages 1087—1097

DOI https://doi.org/10.2147/CMAR.S285451

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 5

Editor who approved publication: Dr Ahmet Emre Eşkazan


Yuqiu Xu,* Qingyang Feng,* Yijiao Chen,* Yihao Mao,* Zhiyuan Zhang, Yang Lv, Peng Zheng, Shanchao Yu, Guodong He, Jianmin Xu

Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Jianmin Xu; Guodong He
Department of General Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, People’s Republic of China
Tel +8621-6404-1990
Fax +8621-6403-8038
Email xujmin@aliyun.com; angelhgd@163.com

Purpose: Colorectal cancer (CRC) is one of the most common malignant tumors worldwide. Ovarian metastases (OM), which are low in frequency, are reported to occur in 3– 14% of women with CRC and have a poor prognosis. Studies have shown that surgical treatment may benefit patients with ovarian metastases arising from CRC. However, the precise benefit of surgery is uncertain. This study was implemented to identify treatment outcomes associated with ovarian metastases from CRC, as well as to clarify the importance of primary and metastatic lesion resection.
Patients and Methods: Between January 2008 and December 2018, the medical records of 93 patients diagnosed with CRC ovarian metastases (CRC-OM) at Zhongshan Hospital, Fudan University, Shanghai, were retrospectively analyzed. Clinicopathological characteristics as well as prognostic conditions were evaluated. Nineteen patients with only synchronous OM and 38 patients without metastases were matched to compare surgical outcomes.
Results: The median overall survival (OS) of the total 93 CRC-OM patients was 26 months. The median OS times of patients with ovary-only metastases (n=37) and those with other metastases (n=56) were 49 months and 20 months, respectively. Patients with only ovarian metastases had a longer OS time (p< 0.001) than patients with other metastases. Patients with ovarian metastases resected (n=76) (p< 0.001) had a longer OS time than those unresected (n=17). Synchronous (n=54) and metachronous (n=39) metastases indicated no significant survival difference. Patients with only ovarian metastases could achieve similar OS times to those of patients without metastases after primary and metastasis surgery.
Conclusion: Surgical treatment is very important for CRC-OM patients. Primary and metastatic lesion resection can help achieve longer survival times.

Keywords: colorectal cancer, metastases, ovary, prognosis

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