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Short-Term Efficacy and Safety of Switching from a Latanoprost/Timolol Fixed Combination to a Latanoprost/Carteolol Fixed Combination

Authors Inoue K, Piao H, Iwasa M, Ishida K, Tomita G

Received 29 November 2019

Accepted for publication 17 March 2020

Published 4 May 2020 Volume 2020:14 Pages 1207—1214

DOI https://doi.org/10.2147/OPTH.S240425

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser


Kenji Inoue,1 Hua Piao,1 Mayumi Iwasa,1 Kyoko Ishida,2 Goji Tomita2

1Inouye Eye Hospital, Tokyo, Japan; 2Department of Ophthalmology, Toho University Ohashi Medical Center, Tokyo, Japan

Correspondence: Kenji Inoue
Inouye Eye Hospital, Chiyoda-ku, Tokyo, Japan
Tel +81 3 3295 0911
Fax +81 3 3295 0917
Email inoue-k@inouye-eye.or.jp

Purpose: To investigate the short-term intraocular pressure-lowering efficacy and safety of switching from a fixed combination of latanoprost/timolol to a fixed combination of latanoprost/carteolol.
Patients and Methods: The subjects were 30 eyes of 30 adult patients with primary open-angle glaucoma, normal-tension glaucoma, or ocular hypertension who were using a latanoprost-/timolol-fixed combination with insufficient intraocular pressure-lowering efficacy or adverse reactions. The subjects were switched from once-daily latanoprost/timolol to once-daily latanoprost/carteolol with no washout interval. Intraocular pressure, tear film break-up time, corneal epithelial defects, conjunctival hyperemia, blood pressure, and pulse rate were measured and compared before and 1 and 3 months after switching. Patients were monitored for adverse reactions at each visit, and dropouts were recorded.
Results: The mean intraocular pressure at 1 month (15.9± 3.1 mmHg) and 3 months (16.3± 3.8 mmHg) was not significantly different from that at baseline (16.1± 3.1 mmHg). The tear film break-up time and corneal epithelial defects were significantly improved after switching (p< 0.01 and p< 0.0001, respectively). There was a significant decrease in systolic blood pressure after 1 month and diastolic pressure after 3 months (p< 0.05). There was no significant change in pulse rate during the study. Adverse reactions (blurred vision, blepharitis, and conjunctival hyperemia) occurred in 3 patients (10.0%). Four patients (13.3%) discontinued treatment during the 3-month study period.
Conclusion: A switch from a fixed combination of latanoprost/timolol to that of latanoprost/carteolol can maintain intraocular pressure and adherence with once-daily administration while improving tear film break-up time and corneal epithelial defects.

Keywords: adverse reactions, eye drops, glaucoma, intraocular pressure

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