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Shelterin Complex at Telomeres: Implications in Ageing

Authors Mir SM, Samavarchi Tehrani S, Goodarzi G, Jamalpoor ‎ Z, Asadi J, Khelghati N, Qujeq D, Maniati M

Received 1 April 2020

Accepted for publication 18 May 2020

Published 3 June 2020 Volume 2020:15 Pages 827—839

DOI https://doi.org/10.2147/CIA.S256425

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Richard Walker


Seyed Mostafa Mir,1– 3 Sadra Samavarchi Tehrani,4,5 Golnaz Goodarzi,4,5 Zahra Jamalpoor,1 Jahanbakhsh Asadi,6 Nafiseh Khelghati,7 Durdi Qujeq,2,3 Mahmood Maniati8

1Trauma Research Center, AJA University of Medical Sciences, Tehran, Iran; 2Student Research Committee, Babol University of Medical Sciences, Babol, Iran; 3Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; 4Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 5Student Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran; 6Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran; 7Department of Clinical Biochemistry, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran; 8School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Correspondence: Zahra Jamalpoor
Trauma Research Center, AJA University of Medical Sciences, Tehran, Iran
Tel +989126011941
Email z_jamalpoor2000@yahoo.com

Abstract: Different factors influence the development‎ and control of ageing. It is well known that progressive telomere shorting is one of the molecular mechanisms underlying ageing. The shelterin complex consists of six telomere-specific proteins which are involved in the protection of chromosome ends. More particularly, this vital complex protects the telomeres from degradation, prevents from activation of unwanted repair systems, regulates the activity of telomerase, and has a crucial role in cellular senescent and ageing-related pathologies. This review explores the organization and function of telomeric DNA along with the mechanism of telomeres during ageing, followed by a discussion of the critical role of shelterin components and their changes during ageing.

Keywords: ageing, sheltering complex, telomeres

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