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Sexual behavior and infection with cervical human papillomavirus types 16 and 18

Authors Itarat Y, Kietpeerakool C, Jampathong N, Chumworathayi B, Kleebkaow P, Aue-aungkul A, Nhokaew W

Received 5 June 2019

Accepted for publication 1 August 2019

Published 26 August 2019 Volume 2019:11 Pages 489—494


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor Elie Al-Chaer

Yuwadee Itarat, Chumnan Kietpeerakool, Nampet Jampathong, Bandit Chumworathayi, Pilaiwan Kleebkaow, Apiwat Aue-aungkul, Wilasinee Nhokaew

Department of Obstetrics and Gynaecology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand

Correspondence: Chumnan Kietpeerakool
Department of Obstetrics and Gynaecology, Faculty of Medicine, Khon Kaen University, 123 Mittraphap Road, Nai-Muang, Muang District, Khon Kaen 40002, Thailand

Objective: This study assessed whether sexual behavior, including engaging in early sexual intercourse and having had multiple sexual partners, can predict the risk of infection with cervical human papillomavirus (HPV) types 16 and 18.
Methods: Records were reviewed of women who underwent cervical cancer screening and were found to be infected with high-risk HPV. The genotypes of high-risk HPV were categorized as HPV 16, HPV 18, and other than 16 or 18. Early sexual intercourse was defined as first sexual intercourse at the age of 19 years or younger. Multiple sexual partners was defined as having more than three lifetime sexual partners. Associations between sexual behavior and HPV 16/18 infection were presented as odds ratios (ORs) and 95% confidence intervals (CIs).
Results: Of the 349 women included in the study, 72 (20.6%) and 30 (8.6%) were infected by HPV 16 and 18, respectively. Eighty-two women (26.0%) reported having engaged in early sexual intercourse, and 33 (10.4%) reported having had multiple sexual partners. After adjustment for age, parity, and smoking habits, we found that women who had engaged in early sexual intercourse tended to have a higher risk of HPV 16 (OR 1.74; 95% CI 0.93–3.29), and those who had had multiple sexual partners were found to be at a significantly higher risk for HPV 18 (OR 4.58; 95% CI 1.44–14.58).
Conclusion: Sexual behavior was associated with an increased risk of HPV 16/18 infection. Engaging in early sexual intercourse increased the risk of HPV 16 infection, and having had multiple sexual partners increased that of HPV 18.

Keywords: sexual behavior, human papillomavirus, cervical neoplasia, sexual partner

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