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Severe Gastrointestinal Involvement in Pediatric Stevens-Johnson Syndrome: A Case Report and Review of the Literature

Authors Bechek S, Garcia M, Chiou H

Received 25 June 2020

Accepted for publication 11 August 2020

Published 30 September 2020 Volume 2020:13 Pages 377—383


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Wing-Kin Syn

Sophia Bechek,1 Manuel Garcia,2 Howard Chiou3

1Stanford University School of Medicine, Stanford, CA, USA; 2Division of Pediatric Gastroenterology, Stanford University School of Medicine, Stanford, CA, USA; 3Department of Medicine, Santa Clara Valley Medical Center, San Jose, CA, USA

Correspondence: Sophia Bechek
Stanford University School of Medicine, 291 Campus Drive, Stanford, CA 94035, USA
Tel +1 650-723-6861

Abstract: Stevens-Johnson syndrome and toxic epidermal necrolysis form a rare but severe disease spectrum characterized by widespread epidermal detachment. Gastrointestinal manifestations of the disease, however, are rarely described in the pediatric literature and have a high mortality among adults. There are limited data on the treatment of these cases, with conflicting evidence regarding the benefit of steroids, IVIG, or other immunosuppressive agents. We review previous instances of gastrointestinal involvement in children and report the case of a previously healthy 13-year-old who presented with the typical ocular and skin findings of Stevens-Johnson syndrome, subsequently developed severe life-threatening diarrhea, and was found to have severe esophagitis, duodenitis, and colitis on endoscopic evaluation. Treatment was initiated with an immediate, short course of steroids along with early introduction of an enteral diet via nasogastric tube, and resulted in full gastrointestinal recovery. This case highlights successful medical treatment of the first reported pediatric case of SJS/TEN with both upper and lower gastrointestinal tract involvement.

Keywords: Stevens-Johnson syndrome, gastrointestinal involvement, diarrhea, steroids, enteral nutrition

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