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Serum TSLP is a potential biomarker of psoriasis vulgaris activity

Authors El-Ghareeb MI, Helmy A, Al Kazzaz S, Samir H

Received 18 April 2019

Accepted for publication 20 June 2019

Published 30 July 2019 Volume 2019:9 Pages 59—63

DOI https://doi.org/10.2147/PTT.S212774

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 3

Editor who approved publication: Professor Uwe Wollina


Mohamed Ibrahim El-Ghareeb,1 Afaf Helmy,1 Sally Al Kazzaz,2 Hanan Samir3

1Department of Dermatology, Zagazig University, Zagazig, Egypt; 2Dermatology, Zagazig General Hospital, Zagazig, Egypt; 3Clinical Pathology, Zagazig University, Zagazig, Egypt

Background: The proallergic cytokine, thymic stromal lymphopoietin (TSLP) may synergize with T cell–derived CD40 ligand (CD40L) to allow IL-23 production in patients with psoriasis. IL-23 is a central cytokine that mediates the inappropriate immune reaction in patients with psoriasis.
Objective: The aim of the study was to correlate serum level of TSLP with psoriasis severity.
Methods: The study was carried out on 53 patients with psoriasis. They were divided into mild, moderate, and severe according to PASI score. The patients’ ages ranged from 10 to 62 years. The patients included 29 males and 24 females. A total of 53 healthy subjects with matched age and sex served as control group. Blood samples were collected from the venous blood of the patients and control subjects then the serum was separated. The serum samples were immediately frozen at -20°C. Serum TSLP was measured by Sandwich Enzyme–linked Immunosorbant Assay (ELISA).
Results: There was a statistically very highly significant increase (p<0.001) in serum TSLP levels among the case group (1042.7±812.93) compared to the control group (314.21±220.78). There was also a statistically very highly significant increase (p<0.001) in serum TSLP levels with increased psoriasis severity estimated by PASI score.
Conclusion: In this study, we found that serum TSLP is elevated in psoriasis patients and is correlated with disease severity.

Keywords: TSLP, psoriasis vulgaris, serum biomarker


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