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Serum miR-4530 sensitizes breast cancer to neoadjuvant chemotherapy by suppressing RUNX2

Authors Wang XX, Ye FG, Zhang J, Li JJ, Chen QX, Lin PY, Song CG

Received 25 April 2018

Accepted for publication 16 July 2018

Published 9 October 2018 Volume 2018:10 Pages 4393—4400

DOI https://doi.org/10.2147/CMAR.S172205

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Cristina Weinberg

Peer reviewer comments 2

Editor who approved publication: Dr Antonella D'Anneo


Xiao-Xiao Wang,1,* Fu-Gui Ye,2,* Jie Zhang,1,* Jun-Jing Li,1 Qing-Xia Chen,1 Pei-Yang Lin,1 Chuan-Gui Song1

1Department of Breast Surgery, Affiliated Union Hospital, Fujian Medical University, Fuzhou, People’s Republic of China; 2Department of Breast Surgery, Key Laboratory of Breast Cancer, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China

*These authors contributed equally to this work

Purpose: Neoadjuvant chemotherapy (NAC) plays a pivotal role in the treatment of locally advanced breast cancer (LABC); however, breast cancer is a heterogeneous disease, individual responses to chemotherapy are highly variable. Therefore, the purpose of the current research is to identify biomarkers that can predict the chemotherapeutic response.
Patients and methods: We recruited 78 patients with primary breast cancer who underwent taxane- and anthracycline-based NAC; these patients were divided into sensitive and resistant groups according to the Response Evaluation Criteria in Solid Tumors (RECIST) criteria. The microRNA microarray was conducted to explore differentially expressed miRNAs. Quantitative real-time polymerase chain reaction (qRT-PCR) further validated the relationship between miR-4530 and chemosensitivity in breast cancer patients.
Results: No significant differences were observed between the two groups regarding the clinicopathological characteristics. miR-4530 showed the most potential involving breast cancer chemosensitivity. Mechanically, RUNX2 was identified one of the direct targets of miR-4530 and responsible for breast cancer chemosensitivity.
Conclusion: Our results revealed that elevated serum miR-4530 levels may sensitize breast cancer to taxane- and anthracycline-based NAC by suppressing RUNX2; therefore, this miRNA has the potential to be a new biomarker for predicting breast cancer chemosensitivity.

Keywords: miR-4530, serum, neoadjuvant chemotherapy, chemotherapeutic resistance, RUNX2

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