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Serum levels of trace minerals and heavy metals in severe COPD patients with and without pulmonary hypertension

Authors Asker S, Asker M, Yeltekin AC, Aslan M, Ozbay B, Demir H, Turan H

Received 2 February 2018

Accepted for publication 5 April 2018

Published 31 May 2018 Volume 2018:13 Pages 1803—1808

DOI https://doi.org/10.2147/COPD.S164431

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Charles Downs

Peer reviewer comments 2

Editor who approved publication: Dr Richard Russell

Selvi Asker,1 Muntecep Asker,2 Asli Cilingir Yeltekin,3 Mehmet Aslan,4 Bulent Ozbay,5 Halit Demir,3 Hakan Turan3

1Department of Chest Diseases, Faculty of Medicine, Dursun Odabas Medical Center, Van Yuzuncu Yil University, Van, Turkey; 2Department of Cardiology, Medical Faculty, Van Yuzuncu Yil University, Van, Turkey; 3Department of Chemistry, Faculty of Science, Van Yuzuncu Yil University, Van, Turkey; 4Department of Internal Medicine, Faculty of Medicine, Van Yuzuncu Yil University, Van, Turkey; 5Department of Chest Diseases, Medical Faculty, Mugla University, Mugla, Turkey

Aim: The aim of the current study was to assess the serum levels of trace minerals/heavy metals in COPD patients with and without pulmonary hypertension (PH) and to investigate their correlations to demographic, clinical, and biochemical variables.
Materials and methods: This cross-sectional study was performed in Van Yuzuncu Yil University Medical Faculty between April 2013 and July 2013. Cases were allocated into three groups: Group 1 consisted of severe COPD patients; Group 2 was made up of COPD patients with PH; and healthy controls constituted Group 3. Demographic, radiological, and biochemical variables, as well as the serum levels of trace minerals and heavy metals, were noted and compared in these three groups.
Results: COPD patients were older and had higher rates of smoking habit, diabetes mellitus, and hypertension compared to the control group. Carotid intima-media thickness was increased bilaterally, and serum levels of Co, Cu, and Fe were higher in COPD patients. Left carotid intima-media thickness was increased, and serum levels of Cd, Co, and Fe were found to be higher in COPD cases with PH compared to COPD patients without PH.
Conclusion: Our results show that serum levels of trace minerals and heavy metals may be altered in COPD and PH.

Keywords: pulmonary hypertension, chronic obstructive pulmonary disease

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