Serum Exosome-Derived miR-139-5p as a Potential Biomarker for Major Depressive Disorder
Received 17 August 2020
Accepted for publication 8 October 2020
Published 10 November 2020 Volume 2020:16 Pages 2689—2693
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Yuping Ning
Jia-Quan Liang,1,* Hai-Rong Liao,1,* Cai-Xia Xu,1 Xiao-Ling Li,1 Ze-Xu Wei,2 Guo-Jun Xie,1 Yong Cheng1,2
1Department of Psychiatry, The Third People’s Hospital of Foshan, Foshan, Guangdong, People’s Republic of China; 2Center on Translational Neuroscience, Minzu University of China, Beijing, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Guo-Jun Xie; Yong Cheng Email email@example.com; firstname.lastname@example.org
Background: MicroRNAs (miRs) have been suggested to be biomarkers to inform the diagnosis of major depressive disorder (MDD). We have previously shown that exosome-derived miR-139-5p had potential in differentiating between patients with MDD and healthy control (HC) subjects.
Materials and Methods: To validate the potential of exosome-derived miR-139-5p as a biomarker for MDD, here we recruited 30 patients with MDD and 30 HC subjects, and used TaqMan probes to detect serum exosomal miR-139-5p levels.
Results: The data showed that patients with MDD had significantly increased exosomal miR-139-5p levels when compared with controls. Correlation analysis suggested that sex, age, and body mass index did not significantly affect blood exosomal miR-139-5p levels in the tested subjects. The ROC curve showed that serum-derived miR-139-5p had reasonable performance in discriminating patients with MDD and HC subjects, with a sensitivity of 0.867 and specificity of 0.767, and the AUC was 0.807.
Discussion: Taken together, these results demonstrated that patients with MDD were accompanied by significantly increased blood exosomal miR-139-5p levels, and exosomal miR-139-5p is a promising biomarker for the diagnosis of MDD.
Keywords: major depressive disorder, exosome, miR-139-5p, biomarker
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