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Secukinumab in the treatment of psoriasis: patient selection and perspectives

Authors Yang EJ, Beck KM, Liao W

Received 1 June 2018

Accepted for publication 20 September 2018

Published 17 October 2018 Volume 2018:8 Pages 75—82

DOI https://doi.org/10.2147/PTT.S146004

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 4

Editor who approved publication: Professor Uwe Wollina


Eric J Yang,1,2 Kristen M Beck,1 Wilson Liao1

1Department of Dermatology, University of California San Francisco, San Francisco, CA, USA; 2Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA

Abstract: Secukinumab is a human monoclonal antibody targeting IL-17A that has been approved for three indications: moderate-to-severe plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis. In Phase III clinical trials for each of these three indications, secukinumab has proven to be both highly efficacious and well-tolerated. However, several biologic medications are currently approved for the treatment of moderate-to-severe plaque psoriasis, and many demonstrate excellent efficacy and safety. Due to this wide selection, it is often unclear how to choose biologics for specific patients. Important considerations in biologic selection include clinical efficacy, safety, cost, convenience, onset of action, and management of comorbid disease. This article aims to outline the key considerations in patient selection for the treatment of plaque psoriasis with secukinumab.

Keywords: secukinumab, IL-17 inhibitor, IL-17A, biologics, psoriasis, patient selection

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