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Sebusuppressive efficacy of the antioxidant bis-ethylhexyl hydroxydimethoxy benzylmalonate in the treatment of oily and blemished skin

Authors Gerlach N, Graf R, Witte G, Lefort M, Pfluecker F, Heinrich H, Tronnier H

Received 5 April 2012

Accepted for publication 24 May 2012

Published 20 August 2012 Volume 2012:5 Pages 101—109

DOI https://doi.org/10.2147/CCID.S32669

Review by Single-blind

Peer reviewer comments 1

Nicole Gerlach,1 Ruediger Graf,2 Gabriele Witte,2 Marina Lefort,2 Frank Pfluecker,2 Ulrike Heinrich,1 Hagen Tronnier1

1DermaTronnier, University of Witten-Herdecke, Witten, Germany; 2Merck KGaA, Darmstadt, Germany

Abstract: The aim of this study was to assess the effect of 2% bis-ethylhexyl hydroxydimethoxy benzylmalonate (HDBM; RonaCare® AP) as an active ingredient in the treatment of oily and blemished skin. This study was carried out as a randomized, placebo-controlled, single-blind study on 44 test subjects with blemished skin over a period of 8 weeks. Sebum measurement, skin inflammation/redness scoring by an expert, photographic documentation and a self-assessment with regard to skin improvement, and tests of skin compatibility and galenic characteristics were performed. Treatment with 2% HDBM resulted in a significant reduction of sebum excretion and showed efficacy against inflamed/red lesions also shown by photographic documentation. Efficacy and galenic performance of 2% HDBM were judged to be superior to the placebo emulsion. Additionally, 2% HDBM was well tolerated; approximately 80% of the test subjects rated the compatibility as good to very good.

Keywords: oily and blemished skin, sebum excretion, antiseborrheic, anti-inflammatory, bis-ethylhexyl hydroxydimethoxy benzylmalonate (HDBM)

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