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Safety and tolerability of macitentan in the management of pulmonary arterial hypertension: an update

Authors Wong AK, Channick RN

Received 30 January 2019

Accepted for publication 12 July 2019

Published 3 September 2019 Volume 2019:11 Pages 71—85


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Rajender R Aparasu

Alexandra K Wong,1 Richard N Channick2

1Division of Pulmonary and Critical Care, Massachusetts General Hospital, Boston, MA 02114, USA; 2Division of Pulmonary and Critical Care, University of California Los Angeles Medical Center, Los Angeles, CA 90095, USA

Correspondence: Alexandra K Wong
Division of Pulmonary and Critical Care, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
Tel +1 617 724 9674
Fax +1 617 726 6878
Email [email protected]

Abstract: Macitentan is a medication in the endothelin receptor antagonist class, approved for treatment of pulmonary arterial hypertension in 2013 based on the results of the pivotal SERAPHIN Trial (Study with an Endothelin Receptor Antagonist in Pulmonary arterial Hypertension to Improve cliNical outcome). Macitentan was shown in initial trials to reduce the likelihood of a morbidity/mortality event. Real-world use of this medication additionally reveals a reduced risk of hospitalizations related to pulmonary arterial hypertension, improved health-related quality of life scores, potential clinical utility in other conditions (such as chronic thromboembolic pulmonary hypertension and pulmonary hypertension related to congenital heart disease), and has a similar safety profile as demonstrated in initial trials.

Keywords: macitentan, pulmonary arterial hypertension, safety, tolerability, efficacy

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