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Safety and efficacy of cilostazol in the management of intermittent claudication

Authors Chi Y, Lavie CJ, Milani RV, White CJ

Published 5 December 2008 Volume 2008:4(6) Pages 1197—1203

DOI https://doi.org/10.2147/VHRM.S3160

Review by Single-blind

Peer reviewer comments 5


Yung-Wei Chi, Carl J Lavie, Richard V Milani, Christopher J White

Department of Cardiology, Ochsner Clinic Foundation, New Orleans, LA, USA

Abstract: Peripheral arterial disease (PAD) is a major health problem affecting millions of patients worldwide. Many will suffer from intermittent claudication (IC), which leads to marked impairment of quality of life (QoL). Besides surgical and endovascular interventions to improve limb-specific outcomes, pharmacotherapy is an effective tool in the treatment of IC. Cilostazol, a Federal Drug Administration-approved medication for the treatment of IC, has demonstrated consistent efficacy in improving exercise capacity and overall health-related QoL. This manuscript will review the pharmacokinetics, safety, and efficacy of cilostazol in the treatment of patients with IC as well as compare this agent with other proven non-invasive therapies for PAD.

Keywords: peripheral arterial disease, cilostazol, intermittent claudication, supervised exercise therapy

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