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Role of small GTPases in polarized vesicle transport to primary cilium

Authors Rao K, Khanna H

Received 19 October 2014

Accepted for publication 10 December 2014

Published 18 February 2015 Volume 2015:6 Pages 17—24

DOI https://doi.org/10.2147/RRB.S57087

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Professor Zvi Kelman

Kollu Nageswara Rao, Hemant Khanna

Department of Ophthalmology, Albert Sherman Center, University of Massachusetts Medical School, Worcester, MA, USA


Abstract: Small GTPases play crucial roles in regulating polarized vesicle trafficking in a cell. These molecules are involved in diverse pathways and regulate cell shape, organelle integrity, and cell signaling. One of the most important cellular signaling centers is the primary or sensory cilium. Small GTPases orchestrate a diverse set of events to not only generate these structures but also mediate their function and maintenance during the life of the cell. In this review, we will discuss the various small GTPases involved in regulating cilia biogenesis and function and their involvement in human diseases.

Keywords: ciliopathies, RPGR, RP2, retina, kidney, photoreceptor, neuronal cilia

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