Back to Browse Journals » Research and Reports in Urology » Volume 3

Role of HMG-CoA reductase inhibitors with curative radiotherapy in men with prostate cancer

Authors Solanki AA, Liauw SL

Published Date June 2011 Volume 2011:3 Pages 95—104

DOI http://dx.doi.org/10.2147/RRU.S14245

Published 15 June 2011

Abhishek A Solanki, Stanley L Liauw
Department of Radiation and Cellular Oncology, University of Chicago Medical Center, Chicago, IL, USA

Abstract: Brachytherapy and external beam radiotherapy are effective and commonly used treatment modalities in men with localized prostate cancer. In this review, we explore the role of radiation therapy in the curative management of prostate cancer, including the use of conformal therapeutic techniques to allow for the escalation of radiation doses to tumor, along with the use of combined radiation and hormonal therapy to enhance disease outcomes in men with aggressive disease. We also review the possible anticancer role of HMG-CoA reductase inhibiting agents (statins) in men with prostate cancer. Laboratory evidence suggests that statins may have antineoplastic effects when used alone and may sensitize cells to radiation therapy when given in combination. We explore the biologic basis for an anticancer effect and the clinical evidence suggesting statins may aid in improving outcomes with radiation therapy for localized prostate cancer.

Keywords:
HMG-CoA reductase inhibitors, statins, radiotherapy, prostate cancer

Download Article [PDF] 

Creative Commons License This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php

Other articles by this author:

Readers of this article also read:

Cost analysis of adjuvant management strategies in early stage (stage I) testicular seminoma

Cox JA, Gajjar SR, Lanni Jr TB, Swanson TA

Research and Reports in Urology 2015, 7:1-7

Published Date: 8 January 2015

Hapten-enhanced therapeutic effect in advanced stages of lung cancer by ultra-minimum incision personalized intratumoral chemoimmunotherapy therapy

Yu BF, Lu YF, Gao F, Jing P, Han W, Zhang PC, Liu GL, Ru N, Cui GH, Xu XH, Sun CL, Guan CJ, Che YB, Wu YL, Ma ZL, Fu Q, Liu J, Wang HY

Lung Cancer: Targets and Therapy 2015, 6:1-11

Published Date: 7 January 2015

Treating cutaneous squamous cell carcinoma using 5-aminolevulinic acid polylactic-co-glycolic acid nanoparticle-mediated photodynamic therapy in a mouse model

Wang X, Shi L, Tu Q, Wang H, Zhang H, Wang P, Zhang L, Huang Z, Zhao F, Luan H, Wang X

International Journal of Nanomedicine 2015, 10:347-355

Published Date: 6 January 2015

Smart homecare technologies for the visually impaired: recent advances

Andò B, Baglio S, Lombardo CO, Marletta V

Smart Homecare Technology and TeleHealth 2015, 3:9-16

Published Date: 22 December 2014

Copeptin in heart failure

Lasota B, Mizia-Stec K

Research Reports in Clinical Cardiology 2014, 5:133-144

Published Date: 1 July 2014

Diagnosis and clinical management of aortic dissection

Harrington PB, Davies JE, Melby SJ

Research Reports in Clinical Cardiology 2014, 5:123-132

Published Date: 19 June 2014

Characteristics, treatment patterns, and unmet needs of Japanese patients with atrial fibrillation

Koretsune Y, Rossi B, Iwamoto K, Wang ECY, DiBonaventura M, Briere JB

Research Reports in Clinical Cardiology 2013, 4:97-105

Published Date: 4 July 2013

8-isorpostanes – markers for oxidative stress in obstructive sleep apnea patients with systolic dysfunction

Cherneva RV, Georgiev OB, Petrova DS, Manov EI, Ruseva SR, Mitev VI, Petrova JI

Research Reports in Clinical Cardiology 2013, 4:67-75

Published Date: 7 June 2013

Effect of weight loss on urinary incontinence in women

Whitcomb EL, Subak LL

Research and Reports in Urology 2011, 3:123-132

Published Date: 1 August 2011