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Role of GSDMB in Pyroptosis and Cancer

Authors Li L, Li Y, Bai Y

Received 22 January 2020

Accepted for publication 4 April 2020

Published 30 April 2020 Volume 2020:12 Pages 3033—3043

DOI https://doi.org/10.2147/CMAR.S246948

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Kenan Onel


Lisha Li, Yanjing Li, Yuxian Bai

Department of Gastrointestinal Oncology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150081, People’s Republic of China

Correspondence: Yanjing Li; Yuxian Bai
Department of Gastrointestinal Oncology, Harbin Medical University Cancer Hospital, 150 Haping Street, Nangang District, Harbin 150081, People’s Republic of China
Tel +86-451-86298303
Fax +86-451-86298961
Email liyanjing_hmu@126.com; bai_yuxian@126.com

Abstract: Gasdermin B (GSDMB) belongs to the gasdermin (GSDM) family which may adopt different mechanisms of intramolecular domain interactions to modulate their lipid-binding and pore-forming activities. The GSDM family has regulatory functions in cell proliferation and differentiation, especially in pyroptosis process. Pyroptosis is a pro-inflammatory form of regulated cell death and is designed to attract a nonspecific innate response to the site of infection. For cancer cells, the activation of pyroptosis may promote cell death and exert anticancer properties. Also, recent studies have observed the pyroptosis-like features in GSDMB and some researches have shown that GSDMB overexpression occurred in several kinds of cancers; these findings bring a contradiction with the participation of GSDMB in pyroptosis. Although people pay less attention to GSDMB, it still has some essential research value. It is a paradox that GSDMB might participate in programmed cell death, which might put forward a research direction of therapeutic targets for cancer. Here, we review the possible progress of how GSDMB participated in this inflammatory regulation mechanistically and the potential functions of GSDMB in cancer.

Keywords: GSDMB, pyroptosis, cancer, gasdermin family, pore-forming activities

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