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Role of exosomal small RNA in prostate cancer metastasis

Authors Zhan F, Shen J, Wang R, Wang L, Dai Y, Zhang Y, Huang X

Received 10 April 2018

Accepted for publication 2 June 2018

Published 28 September 2018 Volume 2018:10 Pages 4029—4038

DOI https://doi.org/10.2147/CMAR.S170610

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Professor Nakshatri


Fei Zhan,1 Jingling Shen,2 Ruitao Wang,3 Liang Wang,4 Yao Dai,5 Yanqiao Zhang,1 Xiaoyi Huang6,7

1Department of Gastrointestinal Medical Oncology, Tumor Hospital of Harbin Medical University, Harbin 150081, China; 2Department of Histology and Embryology, Harbin Medical University, Harbin 150081, China; 3Department of Internal Medicine, Tumor Hospital of Harbin Medical University, Harbin 150081, China; 4Department of Pathology and MCW Cancer Center, Medical College of Wisconsin, Milwaukee, WI, 53226, USA; 5Department of Radiation Oncology, University of Florida, Gainesville, FL, 32610, USA; 6Biotherapy Center, Tumor Hospital of Harbin Medical University, Harbin 150081, China; 7Center of Translational Medicine, Harbin Medical University, Harbin 150086, China

Abstract: Prostate cancer (PCa) is the second most common cancer in men worldwide. When the disease becomes metastatic, limited treatment strategies exist, and metastatic disease prognoses are difficult to predict. Recently, evidence has emerged, which indicates that small RNAs are detectable in patient fluids, and exosomal small RNA ectopic expression is correlated with the development, progression, and metastasis of human PCa; however, the role of small RNAs in PCa is only partially understood. In this review, we discuss the research status regarding circulating exosomal small RNAs and applications using these small RNAs in PCa particularly looking at metastatic disease. Exosomal small RNAs could be used as potential biomarkers for the early diagnosis, micrometastasis detection, and prognosis of PCa.

Keywords: prostate cancer, metastases, ncRNA, exosome

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