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Role of cytokines and chemokines in alcohol-induced tumor promotion

Authors Chen D, Zhang F, Ren H, Luo J, Wang S

Received 12 December 2016

Accepted for publication 3 February 2017

Published 17 March 2017 Volume 2017:10 Pages 1665—1671

DOI https://doi.org/10.2147/OTT.S129781

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Manfred Beleut

Peer reviewer comments 4

Editor who approved publication: Dr Carlos Vigil Gonzales

Danlei Chen,1 Fengyun Zhang,1 Haifeng Ren,1 Jia Luo,2 Siying Wang1

1School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, People’s Republic of China; 2Department of Pharmacology and Nutritional Sciences, University of Kentucky, College of Medicine, Lexington, KY, USA


Abstract: Excessive chronic alcohol consumption has become a worldwide health problem. The oncogenic effect of chronic alcohol consumption is one of the leading concerns. The mechanisms of alcohol-induced tumorigenesis and tumor progression are largely unknown, although many factors have been implicated in the process. This review discusses the recent progress in this research area with concentration on alcohol-induced dysregulation of cytokines and chemokines. Based on the available evidence, we propose that alcohol promotes tumor progression by the dysregulation of the cytokine/chemokine system. In addition, we discuss specific transcription factors and signaling pathways that are involved in the action of these cytokines/chemokines and the oncogenic effect of alcohol. This review provides novel insight into the mechanisms of alcohol-induced tumor promotion.

Keywords: alcohol, tumor promotion, cytokines, chemokines, transcription factors, signal transduction, therapy

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