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Role of cartilage-forming cells in regenerative medicine for cartilage repair

Authors Sun L, Reagan MR, Kaplan D

Published 23 September 2010 Volume 2010:2 Pages 85—94

DOI https://doi.org/10.2147/ORR.S7194

Review by Single-blind

Peer reviewer comments 2


Lin Sun1, Michaela R Reagan2, David L Kaplan1,2
1Department of Chemical and Biological Engineering, 2Department of Biomedical Engineering, Tufts University, Medford, MA, USA

Abstract: Currently, cartilage repair remains a major challenge for researchers and physicians due to its limited healing capacity. Cartilage regeneration requires suitable cells; these must be easily obtained and expanded, able to produce hyaline matrix with proper mechanical properties, and demonstrate sustained integration with native tissue. At present, there is a wide variety of possible cell sources for cartilage regeneration. This review explores the diversity of sources for cartilage-forming cells and the distinctive characteristics, advantages, limitations, and potential applications of each cell source. We place emphasis on cell sources used for in vitro and clinical studies.

Keywords: cell sources, cartilage regeneration, stem cells, chondrocytes

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