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Role of capecitabine in treating metastatic colorectal cancer in Chinese patients

Authors Wang F, Wang F, Bai L, Xu R

Received 13 August 2013

Accepted for publication 4 October 2013

Published 2 April 2014 Volume 2014:7 Pages 501—511

DOI https://doi.org/10.2147/OTT.S38843

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2


Feng Wang,* Feng-Hua Wang,* Long Bai, Rui-Hua Xu

Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China

*These authors contributed equally to this work

Abstract: The China Food and Drug Administration approved the use of capecitabine in patients with metastatic colorectal cancer (mCRC) in 2004. This paper reviews the available information of capecitabine in Chinese patients with mCRC, focusing on its effectiveness and safety against mCRC. Identification of all eligible studies was made by searching the PubMed and Wanfang database from 2000 to 2013. Published data examining various aspects of clinical response and tolerability with capecitabine alone or in combination with other chemotherapeutic or biological agents for first- and second-line mCRC were examined. Capecitabine and its combination displayed high efficacy in Chinese patients with mCRC. Toxicities are generally manageable, and elderly patients can tolerate capecitabine well.

Keywords: capecitabine, metastatic colorectal cancer, Chinese

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