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Role of adalimumab in the management of children and adolescents with juvenile idiopathic arthritis and other rheumatic conditions

Authors Marzan K

Received 1 February 2012

Accepted for publication 17 April 2012

Published 20 June 2012 Volume 2012:3 Pages 85—93


Review by Single-blind

Peer reviewer comments 3

Katherine Anne B Marzan

Division of Rheumatology, Children's Hospital Los Angeles, Los Angeles, CA, USA

Abstract: Treatment of children and adolescents with juvenile idiopathic arthritis and other pediatric rheumatic diseases has evolved. Where once there was only a limited arsenal of medications, with significant side effects and inadequate efficacy, today, with an increased understanding of the pathogenesis of these diseases, there is a wider variety of more targeted and effective treatments. TNF-α is a cytokine involved in a number of inflammatory pathways in pediatric rheumatic diseases. The emergence of biologic modifiers that target TNF-α has been pivotal in providing the ability to deliver early and aggressive treatment. Adalimumab, a recombinant monoclonal antibody to TNF-α, is an important therapeutic option, which affords children and adolescents with chronic illnesses an improved quality of life.

Keywords: adalimumab, juvenile idiopathic arthritis, TNF-α, pediatric, rheumatic diseases, treatment

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