Rituximab in severe skin diseases: target, disease, and dose
Daniel D Bennett1, Maro Ohanian2, Christian T Cable2
1Department of Dermatology, 2Department of Internal Medicine, Division of Hematology and Oncology, Scott and White Healthcare, Texas A&M Health Science Center College of Medicine. Temple, TX, USA
Abstract: New clinical indications for rituximab seem to appear every day. This review will trace the use of this monoclonal antibody from lymphoid malignancy, to classic autoimmune disease, and specifically severe autoimmune skin diseases. The history leading to different dosing schema with associated pharmacokinetic data will be discussed. A case of livedoid vasculopathy (atrophie blanche) responding to rituximab will illustrate how the response to therapy can help to elucidate previously obscure pathophysiology.
Keywords: rituximab, livedoid vasculopathy, pharmacokinetics, pemphigus vulgaris, atopic dermatitis, rheumatoid arthritis
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