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Risperidone-induced reversible neutropenia

Authors Kattalai Kailasam V, Chima V, Nnamdi U, Sharma K, Shah K

Received 10 May 2017

Accepted for publication 16 June 2017

Published 25 July 2017 Volume 2017:13 Pages 1975—1977


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Roger Pinder

Vasanth Kattalai Kailasam,1 Victoria Chima,2,* Uchechukwu Nnamdi,3,* Kavita Sharma,4,* Kairav Shah5

1College of Medicine, University of Illinois, Chicago, IL, USA; 2Mount Sinai Beth Israel Medical Center, New York, NY, USA; 3Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA; 4Harlem Hospital Center, New York, NY, USA; 5Department of Psychiatry & Behavioral Sciences, The University of Texas McGovern Medical School, Houston, TX, USA

*These authors contributed equally to this work

Abstract: This case report presents a 44-year-old man with a history of schizophrenia who developed neutropenia on risperidone therapy. The patient’s laboratory reports showed a gradual decline of leukocytes and neutrophils after resolution and rechallenging. This was reversed with the discontinuation of risperidone and by switching to olanzapine. In this case report, we also discuss the updated evidence base for management of risperidone-induced neutropenia.

Keywords: risperidone, antipsychotics, neutropenia, blood dyscrasias

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