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Risk of post-traumatic epilepsy after severe head injury in patients with at least one seizure

Authors Chen W, Li MD, Wang GF, Yang XF, Liu L, Meng FG

Received 10 May 2017

Accepted for publication 20 July 2017

Published 30 August 2017 Volume 2017:13 Pages 2301—2306

DOI https://doi.org/10.2147/NDT.S141486

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Prof. Dr. Roumen Kirov

Peer reviewer comments 2

Editor who approved publication: Professor Wai Kwong Tang


Video abstract presented by Wei Chen.

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Wei Chen,1 Ming-De Li,2 Gui-Fang Wang,1 Xia-Feng Yang,1 Lin Liu,1 Fan-Gang Meng3

1Department of Neurology, Liaocheng People’s Hospital, Liaocheng, 2Department of Neurosurgery, The People’s Hospital in Ling Cheng District, DeZhou, Shandong, 3Department of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China

Background: To explore the incidence and risk factors, including type of seizures for post-traumatic epilepsy (PTE) after severe traumatic brain injury (TBI).
Subjects and methods: This was a retrospective follow-up study of patients discharged from Liaocheng People’s Hospital between March 2011 and June 2015 with a diagnosis of post-traumatic seizures. Risk factors for PTE were evaluated in 68 inpatients by using Kaplan–Meier curves and the Cox model.
Results: Complete clinical information was available for 68 patients. A total of 54 cases (79.4%) were diagnosed as presenting with PTE, occurring from 10 days to 179 months after severe TBI. Nineteen out of 54 cases (35.2%) had been defined as PTE within the first 6 months after the trauma, 17 cases (31.5%) within 7–12 months, 8 cases (14.8%) within 13–24 months, 2 cases (3.7%) within 25–36 months, and 8 cases (14.8%) within 37–179 months after the TBI. The Kaplan–Meier curves demonstrated that simple partial seizures, surgical treatment, and onset of seizures occurring within 6 months after injury were associated with PTE.
Conclusions: The Cox model indicated that, for patients aged >34 years at the time of injury, the PTE risk was 2.55 times greater than for those aged ≤34 years. In addition, simple partial seizures, surgical treatment and onset of seizures occurring within 6 months after injury were significant risk factors for the development of PTE.

Keywords: post-traumatic epilepsy, risk factor, post-traumatic seizure

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