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Risk of Cardiovascular Disease Mortality in Relation to Depression and 14 Common Risk Factors

Authors Jia Z, Li S

Received 14 November 2020

Accepted for publication 13 January 2021

Published 12 February 2021 Volume 2021:14 Pages 441—449


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser

Zhaoqi Jia, Sen Li

School of Life Sciences, Beijing University of Chinese Medicine, Beijing, People’s Republic of China

Correspondence: Sen Li
School of Life Sciences, Beijing University of Chinese Medicine, Beijing, People’s Republic of China

Background: Depression has been linked to a worse prognosis of Cardiovascular disease (CVD), and these two diseases share a variety of common risk factors such as unhealthy lifestyles and chronic medical conditions. However, the potential role of these common risk factors in modulating the association between depression and CVD mortality and whether the co-occurrence of depression and a specific common risk factor has a cumulative impact on CVD mortality are still largely unknown.
Methods: We pooled data from 2005– 2014 of Nation health and nutritional examination survey, leading to a study population of 22,177 adults. The Patient Health Questionnaire was employed to assess the depression symptoms, and information on CVD mortality was obtained from the linked mortality file of NHANES. Fourteen common risk factors of depression and CVD were included in this study.
Results: Based on the interaction analyses, we found overweight was protective for the risk of CVD death in depressive participants, but not in people without depression. Moreover, relative risk-based analyses indicated a mutually promotive effect of depression and baseline CVD or living alone on CVD mortality.
Conclusion: The novel findings in our study may facilitate risk stratification in the clinical programs targeting CVD mortality and help to shed light on the differential pathophysiological mechanisms in the depression-mediated elevation of CVD mortality.

Keywords: depression, cardiovascular disease mortality, epidemiology, NHANES

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