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Risk Factors of Deterioration in Quality of Life Scores in Thyroid Cancer Patients After Thyroidectomy

Authors Li J, Xue LB, Gong XY, Yang YF, Zhang BY, Jin J, Shi QF, Liu YH

Received 19 October 2019

Accepted for publication 4 December 2019

Published 19 December 2019 Volume 2019:11 Pages 10593—10598

DOI https://doi.org/10.2147/CMAR.S235323

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Antonella D'Anneo


Jie Li, Ling Bo Xue, Xiao Yi Gong, Yan Fang Yang, Bu Yong Zhang, Jian Jin, Qing Feng Shi, Yong Hong Liu

Thyroid and Breast Surgery, Cangzhou Central Hospital, Cangzhou City 061000, People’s Republic of China

Correspondence: Yong Hong Liu
Thyroid and Breast Surgery, Cangzhou Central Hospital, No. 16 Xinhua Road, Yunhe Qu, Cangzhou City 061000, People’s Republic of China
Tel +86-15733758110
Fax +86 317-207-2692
Email lyh15733758110@hotmail.com

Objective: Despite the expectation of normal life expectancy for thyroid cancer, there are concerns about the decreased quality of life (QoL). The present study investigated the potential risk factors of deterioration in QoL scores in thyroid cancer patients after thyroidectomy.
Materials and methods: A total of 286 patients who were diagnosed with thyroid cancer after thyroidectomy were involved in this prospective, single-center, observational study from November 2018 to June 2019. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 was used to assess the QoL 3 months after thyroidectomy. We investigated the effects of demographics (age, gender, education, marital status, area of residence, and annual mean income), tumor characteristics (histology, clinical stage, presence of metastasis, surgery type, and radiotherapy), and neurological deficits induced by recurrent nerve or superior laryngeal injury on QoL.
Results: The mean overall QoL in thyroid cancer survivors was 65.93 ±9.00 (on a scale of 0–100, where 100 was the best). Multivariate regression analysis confirmed that clinical stage (P < 0.010), surgery type (P < 0.001), histology (P < 0.001), neurological deficits (P < 0.001), and marital status (P < 0.001) were independent risk factors for decreased QoL 3 months after thyroidectomy.
Conclusion: Our study indicated that clinical stage, surgery type, histology, neurological deficits, and marital status were independent risk factors for decreased QoL at 3 months after thyroidectomy. Further exploration and validation of these findings in larger prospective studies are warranted.

Keywords: quality of life, thyroid cancer, thyroidectomy

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