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Rhabdomyolysis secondary to drug interaction between atorvastatin, omeprazole, and dexamethasone

Authors Elazzazy S, Eziada, Zaidan M

Received 11 June 2012

Accepted for publication 24 July 2012

Published 4 September 2012 Volume 2012:5 Pages 59—61

DOI https://doi.org/10.2147/IMCRJ.S34919

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4


Shereen Elazzazy,1 Saad S Eziada,2 Manal Zaidan1

1Pharmacy Department, 2Oncology Hematology Department, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar

Abstract: Concomitant administration of atorvastatin, omeprazole, and dexamethasone has been shown to increase the serum concentration of serum hydroxymethylglutaryl coenzyme A which can be associated with elevation of creatine kinase and an increased risk of severe myopathy and rhabdomyolysis. In this paper, we report a case of a 60-year-old female patient with stage IV colon cancer and compromised hepatic function receiving palliative care who developed rhabdomyolysis while taking atorvastatin, omeprazole, and dexamethasone. Atorvastatin was stopped, and the dexamethasone dose was decreased. Her case was complicated by urosepsis cultures revealing an extended spectrum β-lactamase-producing strain of Escherichia coli, and she died on the second day after admission. Physicians should evaluate the risk/benefit ratio of continuing statins in palliative care patients, and pay special attention to the monitoring of patients on statins and P-glycoprotein inhibitors regardless of hepatic function.

Keywords: statins, rhabdomyolysis, drug–drug interaction, P-glycoprotein inhibitors

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