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Review of effects of anti-VEGF treatment on refractive error

Authors Mintz-Hittner H, Geloneck M

Received 28 October 2015

Accepted for publication 21 January 2016

Published 15 June 2016 Volume 2016:8 Pages 135—140

DOI https://doi.org/10.2147/EB.S99306

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Professor Margaret Wong-Riley


Helen A Mintz-Hittner,1,2 Megan M Geloneck1,2

1Ruiz Department of Ophthalmology and Visual Science, McGovern Medical School at UTHealth, 2WT and Louise J Moran Pediatric Eye Clinic (affiliate of Robert Cizik Eye Clinic), Houston, TX, USA

Abstract: To examine the effect of anti-vascular endothelial growth factor (anti-VEGF) agents on refractive error in the setting of retinopathy of prematurity (ROP) through a review of the literature, a PubMed search was performed of appropriate search terms, and the results of all relevant studies were extracted and compiled. Eleven relevant articles were identified in the literature, totaling 466 eyes, treated with varied anti-VEGF agents (bevacizumab, ranibizumab, and aflibercept) with mean spherical equivalent refractions ranging from +0.75 D to 3.57 D, with prevalence of high myopia ranging from 0 to 35%. Anti-VEGF monotherapy for ROP leads to low levels of myopia, and there may be a differential effect of specific anti-VEGF agents utilized on refractive outcomes.

Keywords: retinopathy of prematurity, ROP, refraction, myopia, bevacizumab, ranibizumab, aflibercept

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