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Reversal of olanzapine-induced weight gain in a patient with schizophrenia by switching to asenapine: a case report

Authors Okazaki K, Yamamuro K, Kishimoto T

Received 8 August 2017

Accepted for publication 13 October 2017

Published 21 November 2017 Volume 2017:13 Pages 2837—2840


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Editor who approved publication: Dr Taro Kishi

Kosuke Okazaki, Kazuhiko Yamamuro, Toshifumi Kishimoto

Department of Psychiatry, Nara Medical University School of Medicine, Kashihara, Japan

Aims: Antipsychotics are effective for treating schizophrenia, but atypical antipsychotics can cause several adverse side effects including weight gain, hyperprolactinemia, and extrapyramidal symptoms. Moreover, weight gain increases the risk of metabolic diseases.
Methods: We treated a case of olanzapine-induced weight gain in a 41-year-old man with schizophrenia by switching his medication from olanzapine to asenapine.
Results: The weight gain improved after switching the medication, from 80.3 to 75.0 kg, a weight loss of 6.6%, and there was no significant worsening of psychological symptoms or other adverse effects.
Conclusions: Asenapine might be effective for treating patients with schizophrenia who experience olanzapine-induced weight gain.

olanzapine, weight gain, schizophrenia, asenapine

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