Back to Journals » Clinical Interventions in Aging » Volume 1 » Issue 4

Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety

Authors Siddharth Mukherjee, Abhijit Date, Vandana Patravale, Hans Christian Korting, Alexander Roeder, Günther Weindl

Published 15 January 2007 Volume 2006:1(4) Pages 327—348

Siddharth Mukherjee1, Abhijit Date2, Vandana Patravale3, Hans Christian Korting4, Alexander Roeder4, Günther Weindl5
1Department of Pharmacology, Bombay College of Pharmacy, Kalina, Santacruz (E.), Mumbai, India; 2Pharmaceutical R & D, Nicholas Piramal Research Center, Goregaon, Mumbai, India; 3Department of Pharmaceutical Sciences and Technology, University Institute of Chemical Technology, Matunga, Mumbai, India; 4Department of Dermatology and Allergology, Ludwig-Maximilians University, Munich, Germany; 5Department of Dermatology, Eberhard Karls
University Tübingen, Tübingen, Germany

Abstract: Aging of skin is an intricate biological process consisting of two types. While intrinsic or chronological aging is an inevitable process, photoaging involves the premature aging of skin occurring due to cumulative exposure to ultraviolet radiation. Chronological and photoaging both have clinically differentiable manifestations. Various natural and synthetic retinoids have been explored for the treatment of aging and many of them have shown histological and clinical improvement, but most of the studies have been carried out in patients presenting with photoaged skin. Amongst the retinoids, tretinoin possibly is the most potent and certainly the most widely investigated retinoid for photoaging therapy. Although retinoids show promise in the treatment of skin aging, irritant reactions such as burning, scaling or dermatitis associated with retinoid therapy limit their acceptance by patients. This problem is more prominent with tretinoin and tazarotene whereas other retinoids mainly represented by retinaldehyde and retinol are considerably less irritating. In order to minimize these side effects, various novel drug delivery systems have been developed. In particular, nanoparticles have shown a good potential in improving the stability, tolerability and efficacy of retinoids like tretinoin and retinol. However, more elaborate clinical studies are required to confirm their advantage in the delivery of topical retinoids.

Keywords: photoaging, chronological aging, tretinoin, retinaldehyde, tazarotene, nanoparticles

Download Article [PDF] 

Readers of this article also read:

Managing comorbidities in COPD

Hillas G, Perlikos F, Tsiligianni I, Tzanakis N

International Journal of Chronic Obstructive Pulmonary Disease 2015, 10:95-109

Published Date: 7 January 2015

Contraceptive implants: current perspectives

Rowlands S, Searle S

Open Access Journal of Contraception 2014, 5:73-84

Published Date: 23 September 2014

Coronary microvascular endothelial dysfunction is an independent predictor of development of osteoporosis in postmenopausal women

Prasad M, Reriani M, Khosla S, Gössl M, Lennon R, Gulati R, Prasad A, Lerman LO, Lerman A

Vascular Health and Risk Management 2014, 10:533-538

Published Date: 26 August 2014

Comparison of the clinical features and outcomes in two age-groups of elderly patients with atrial fibrillation

Shao XH, Yang YM, Zhu J, Zhang H, Liu Y, Gao X, Yu LT, Liu LS, Zhao L, Yu PF, Zhang H, He Q, Gu XD

Clinical Interventions in Aging 2014, 9:1335-1342

Published Date: 12 August 2014

Biodistribution, kinetics, and biological fate of SPION microbubbles in the rat

Barrefelt A, Saghafian M, Kuiper R, Ye F, Egri G, Klickermann M, Brismar TB, Aspelin P, Muhammed M, Dähne L, Hassan M

International Journal of Nanomedicine 2013, 8:3241-3254

Published Date: 26 August 2013

Effects of low-fat dairy intake on blood pressure, endothelial function, and lipoprotein lipids in subjects with prehypertension or stage 1 hypertension

Maki KC, Rains TM, Schild AL, Dicklin MR, Park KM, Lawless AL, Kelley KM

Vascular Health and Risk Management 2013, 9:369-379

Published Date: 23 July 2013

Hemorrhagic infarction at 33 days after birth in a healthy full-term neonate

Kubo Y, Ogasawara K, Kurose A, Kashimura H, Koji T, Otawara Y, Kamei J, Akasaka M, Sasaki M, Ogawa A

Vascular Health and Risk Management 2011, 7:667-670

Published Date: 8 November 2011

Transdermal hormone therapy and bone health

Lee P Shulman

Clinical Interventions in Aging 2008, 3:51-54

Published Date: 7 March 2008

Cataract surgery and quality of life implications

Daniel Morris, Scott G Fraser, Christopher Gray

Clinical Interventions in Aging 2007, 2:105-108

Published Date: 15 April 2007