Back to Journals » Clinical Ophthalmology » Volume 4

Retinal nerve fiber layer thickness in recovered and persistent amblyopia

Authors Atsushi Miki, Motohiro Shirakashi, Kiyoshi Yaoeda, et al

Published 17 September 2010 Volume 2010:4 Pages 1061—1064

DOI https://doi.org/10.2147/OPTH.S13145

Review by Single-blind

Peer reviewer comments 2

Atsushi Miki1,2, Motohiro Shirakashi1, Kiyoshi Yaoeda1, Yu Kabasawa1, Satoshi Ueki1, Mineo Takagi1, Haruki Abe1
1Department of Ophthalmology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan; 2Department of Ophthalmology, Kawasaki Medical School, Okayama, Japan

Purpose: To investigate, using optical coherence tomography (OCT), whether retinal nerve fiber layer thickness (RNFLT) is affected in amblyopic eyes.
Methods: Using OCT (Stratus OCT™ [Carl Zeiss, Dublin, CA]), the RNFLT was measured in 26 patients with persistent unilateral amblyopia and in 25 patients with recovered unilateral amblyopia. The RNFLT was compared between the affected and fellow eyes in patients with persistent amblyopia and in those with recovered amblyopia, and between the amblyopic eyes of patients with persistent amblyopia and the previously amblyopic eyes of patients with recovered amblyopia.
Results: In patients with persistent amblyopia and in those with recovered amblyopia, the affected eyes were significantly more hyperopic than the fellow eyes. The average (±standard deviation) RNFLT measured 105.5 ± 14.0 µm for the persistently amblyopic eyes; this value did not significantly differ from that of the fellow eyes (105.2 ± 13.0 µm) or the previously amblyopic eyes of recovered amblyopia (107.1 ± 11.7 µm). Also, logistic regression analysis adjusting for refraction showed no significant difference in the RNFLT between the persistently amblyopic eyes and the previously amblyopic eyes.
Conclusions: Our results indicate that there is no significant change in the RNFLT in amblyopic eyes.

Keywords: optical coherence tomography, retinal nerve fiber layer thickness, amblyopia

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF] 

 

Other articles by this author:

Optic nerve head analysis of superior segmental optic hypoplasia using Heidelberg retina tomography

Atsushi Miki, Motohiro Shirakashi, Kiyoshi Yaoeda, et al

Clinical Ophthalmology 2010, 4:1193-1199

Published Date: 11 October 2010

Optic disc measurements using the Heidelberg Retina Tomograph in amblyopia

Atsushi Miki, Motohiro Shirakashi, Kiyoshi Yaoeda, et al

Clinical Ophthalmology 2010, 4:1025-1028

Published Date: 14 September 2010

Pupillography of automated swinging flashlight test in amblyopia

Atsushi Miki, Atsuhiko Iijima, Mineo Takagi, Kiyoshi Yaoeda, Tomoaki Usui, et al

Clinical Ophthalmology 2008, 2:781-786

Published Date: 5 December 2008

Readers of this article also read:

Green synthesis of water-soluble nontoxic polymeric nanocomposites containing silver nanoparticles

Prozorova GF, Pozdnyakov AS, Kuznetsova NP, Korzhova SA, Emel’yanov AI, Ermakova TG, Fadeeva TV, Sosedova LM

International Journal of Nanomedicine 2014, 9:1883-1889

Published Date: 16 April 2014

Methacrylic-based nanogels for the pH-sensitive delivery of 5-Fluorouracil in the colon

Ashwanikumar N, Kumar NA, Nair SA, Kumar GS

International Journal of Nanomedicine 2012, 7:5769-5779

Published Date: 15 November 2012

A novel preparation method for silicone oil nanoemulsions and its application for coating hair with silicone

Hu Z, Liao M, Chen Y, Cai Y, Meng L, Liu Y, Lv N, Liu Z, Yuan W

International Journal of Nanomedicine 2012, 7:5719-5724

Published Date: 12 November 2012

Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy

Deepa G, Thulasidasan AK, Anto RJ, Pillai JJ, Kumar GS

International Journal of Nanomedicine 2012, 7:4077-4088

Published Date: 27 July 2012

Crystallization after intravitreal ganciclovir injection

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Clinical Ophthalmology 2010, 4:709-711

Published Date: 14 July 2010