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Retinal breaks due to intravitreal ocriplasmin

Authors Silva R, Moshfeghi D, Leng T

Received 20 May 2014

Accepted for publication 18 June 2014

Published 25 August 2014 Volume 2014:8 Pages 1591—1594

DOI https://doi.org/10.2147/OPTH.S68037

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5


Ruwan A Silva, Darius M Moshfeghi, Theodore Leng

Byers Eye Institute at Stanford, Stanford University School of Medicine, Palo Alto, CA, USA

Abstract: Ocriplasmin represents a new treatment option for numerous vitreoretinopathies involving an abnormal vitreomacular interface. While the drug may circumvent the traditional risks of surgical treatment, pharmacologic vitreolysis is not devoid of risk itself. This report presents two cases, one of vitreomacular traction syndrome and the other of a full-thickness macular hole, both of which were treated with an intravitreal injection of ocriplasmin. Notably, in both cases, vitreomacular traction of the macula appears to have been alleviated; however, failure to completely relieve vitreoretinal traction from the peripheral retina generated retinal breaks with one patient eventually developing a macula-involving retinal detachment. Thus, even in instances of ‘successful’ pharmacologic treatment of vitreomacular traction, continued follow-up evaluation is essential.

Keywords: posterior vitreous detachment, retinal detachment, vitreomacular traction, ocriplasmin, retinal break, macular hole, laser retinopexy

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