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Resveratrol As A Natural Regulator Of Autophagy For Prevention And Treatment Of Cancer

Authors Tian Y, Song W, Li D, Cai L, Zhao Y

Received 22 April 2019

Accepted for publication 23 September 2019

Published 17 October 2019 Volume 2019:12 Pages 8601—8609

DOI https://doi.org/10.2147/OTT.S213043

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Leo Jen-Liang Su


Yuanyuan Tian,1 Wenjing Song,1 Dan Li,1 Lu Cai,2 Yuguang Zhao1

1Cancer Center, the First Hospital of Jilin University, Changchun, Jilin 130021, People’s Republic of China; 2Departments of Pediatrics, Radiation Oncology, Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, USA

Correspondence: Yuguang Zhao
Cancer Center, the First Hospital of Jilin University, Changchun, Jilin 130021, People’s Republic of China
Tel +8643115804303822
Email zhaoyuguang@jlu.edu.cn

Abstract: Resveratrol, as a natural product compound, has been recently attracted much attention for its potent effects on cancer. Cancer is a serious disease threatening human survival and social development. Autophagy is a cellular pathway to realize the metabolic needs of the cell itself and the renewal of some organelles and plays opposing, context-dependent role in tumorigenesis. So the regulation of autophagy is of great significance in the treatment of cancer. p62, as an autophagy adaptor protein, is a preferred target for autophagy and is constantly controlled by constitutive autophagy. As a tumor-suppression mechanism, autophagy deficiency is common in tumors, which results in aberrant accumulation of p62 and activates p62-regulated pathways, such as activation of mTOR in nutrient sensing, and the activation of the Keap1-Nrf2 pathway for antioxidant stress, which are associated with cancer development. In this review, we emphasize that resveratrol can induce autophagy in the treatment of cancer and accelerates the degradation of p62, and then, the mTOR activation is blocked and Nrf2 activation is suppressed. As a result, the multidrug resistance of cancer cells can be reversed by resveratrol.

Keywords: resveratrol, cancer, autophagy, p62, mTOR, Nrf2

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