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CXCL13 Is a Biomarker of Anti-Leucine-Rich Glioma-Inactivated Protein 1 Encephalitis Patients [Response to Letter]
Received 15 January 2020
Accepted for publication 15 January 2020
Published 30 January 2020 Volume 2020:16 Pages 339—340
Sheng-jun Wang, Xue-wu Liu
Department of Neurology, Qilu Hospital, Shandong University, Ji’nan, People’s Republic of China
Correspondence: Sheng-jun Wang; Xue-wu Liu
Department of Neurology, Qilu Hospital, Shandong University, 107# Wen Hua Xi Road, Ji’nan 250012, People’s Republic of China
Email [email protected]; [email protected]
Thanks for the concerns and comments of Mr. Zuowei Duan. There were indeed some limitations in our published article since it was only a preliminary exploratory research. As for the rarity of LGI1 encephalitis, only sixteen patients were enrolled in our study. The multifactorial analysis of variance was hard to be evaluated. But we do believe the statistical significance of our finding about the increasing of CXCL13 levels in the patients.
We agree that the clinical significance of CXCL13 levels increasing should not be over-estimated by clinicians. We have stated that the increasing of CXCL13 levels were reported in other autoimmune diseases including multiple sclerosis, neuroborreliosis and anti-NMDAR encephalitis in “Discussion Section” of our published article. The specificity and sensitivity of CXCL13 in serum/CSF for autoimmune encephalitis still need to be further investigated. Anyhow, we have found a potential biomarker for the diagnosis of anti-LGI1 encephalitis.
This is in response to the Letter to the Editor
View the original paper by Lin and colleagues.
Dear editor
Thanks for the concerns and comments of Mr. Zuowei Duan. There were indeed some limitations in our published article since it was only a preliminary exploratory research. As for the rarity of LGI1 encephalitis, only sixteen patients were enrolled in our study. The multifactorial analysis of variance was hard to be evaluated. But we do believe the statistical significance of our finding about the increasing of CXCL13 levels in the patients.
We agree that the clinical significance of CXCL13 levels increasing should not be over-estimated by clinicians. We have stated that the increasing of CXCL13 levels were reported in other autoimmune diseases including multiple sclerosis, neuroborreliosis and anti-NMDAR encephalitis in “Discussion Section” of our published article. The specificity and sensitivity of CXCL13 in serum/CSF for autoimmune encephalitis still need to be further investigated. Anyhow, we have found a potential biomarker for the diagnosis of anti-LGI1 encephalitis.
Disclosure
The authors report no conflicts of interest in this communication.
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