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Resolution of foveal detachment in dome-shaped macula after treatment by spironolactone: report of two cases and mini-review of the literature

Authors Dirani A, Matet A, Beydoun T, Mantel I, Behar-Cohen F

Received 11 February 2014

Accepted for publication 17 March 2014

Published 20 May 2014 Volume 2014:8 Pages 999—1002

DOI https://doi.org/10.2147/OPTH.S62267

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5


Ali Dirani,1 Alexandre Matet,1 Talal Beydoun,2 Irmela Mantel,1 Francine Behar-Cohen1–3

1Department of Ophthalmology, University of Lausanne, Jules Gonin Eye Hospital, Lausanne, Switzerland; 2Department of Ophthalmology, Hôtel-Dieu de Paris Hospital, Assistance Publique – Hôpitaux de Paris, Paris, France; 3Inserm UMRS872, Physiopathology of Ocular Diseases: Therapeutic Innovations, Centre de Recherche des Cordeliers, Paris, France

Abstract: Dome-shaped macula (DSM) was recently described in myopic patients as a convex protrusion of the macula within a posterior pole staphyloma. The pathogenesis of DSM and the development of associated serous foveal detachment (SFD) remain unclear. The obstruction of choroidal outflow and compressive changes of choroidal capillaries have been proposed as causative factors. In this paper, we report two cases of patients with chronic SFD associated with DSM treated with oral spironolactone. After treatment, there was a complete resolution of SFD in both patients. To the best of our knowledge, this is the first report of successful treatment of SFD in DSM by a mineralocorticoid receptor antagonist.

Keywords: serous foveal detachment, mineralocorticoid receptor antagonist, dome-shaped macula, treatment

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