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Resistance to antivascular endothelial growth factor treatment in age-related macular degeneration

Authors Tranos P, Vacalis A, Asteriadis S, Koukoula S, Vachtsevanos A, Perganta G, Georgalas I

Received 30 January 2013

Accepted for publication 2 April 2013

Published 17 June 2013 Volume 2013:7 Pages 485—490

DOI https://doi.org/10.2147/DDDT.S43470

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3


Paris Tranos,1 Athanasios Vacalis,1 Solon Asteriadis,1 Stavrenia Koukoula,1 Athanasios Vachtsevanos,1 Georgia Perganta,1 Ilias Georgalas2

1Retina Centre, Thessaloniki, Greece; 2Department of Ophthalmology, "G Gennimatas" Hospital of Athens, University of Athens, Athens, Greece

Abstract: Age-related macular degeneration (AMD) is the main cause of visual impairment and blindness in people aged over 65 years in developed countries. Vascular endothelial growth factor (VEGF) is a positive regulator of angiogenesis and its proven role in the pathological neovascularization in wet AMD has provided evidence for the use of anti-VEGF agents as potential therapies. In this study, we review the literature for the possible causes of failure after treatment with anti-VEGF agents and attempt to propose an algorithm of suggestive actions to increase the chances of successful management of such difficult cases.

Keywords: antiVEGF, age related macular degeneration, treatment

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