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Resistance and Overcoming Resistance in Breast Cancer

Authors Luque-Bolivar A, Pérez-Mora E, Villegas VE, Rondón-Lagos M

Received 5 July 2020

Accepted for publication 15 September 2020

Published 11 November 2020 Volume 2020:12 Pages 211—229

DOI https://doi.org/10.2147/BCTT.S270799

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Professor Pranela Rameshwar


Andrea Luque-Bolivar,1 Erika Pérez-Mora,1 Victoria Eugenia Villegas,2 Milena Rondón-Lagos1

1School of Biological Sciences, Universidad Pedagógica y Tecnológica de Colombia, Tunja 150003, Colombia; 2Biology Program, Faculty of Natural Sciences, Universidad del Rosario, Bogotá 111221, Colombia

Correspondence: Victoria Eugenia Villegas
Biology Program, Faculty of Natural Sciences, Universidad del Rosario, Bogotá 111221, Colombia
Tel/Fax +57-1-297-0200 Ext 4029
Email victoria.villegas@urosario.edu.co
Milena Rondón-Lagos
School of Biological Sciences, Universidad Pedagógica y Tecnológica de Colombia, Tunja 150003, Colombia
Tel/Fax +57-8-7420-8263
Email sandra.rondon01@uptc.edu.co

Abstract: The incidence and mortality of breast cancer (BC) have increased in recent years, and BC is the main cause of cancer-related death in women worldwide. One of the most significant clinical problems in the treatment of patients with BC is the development of therapeutic resistance. Therefore, elucidating the molecular mechanisms involved in drug resistance is critical. The therapeutic decision for the management of patients with BC is based not only on the assessment of prognostic factors but also on the evaluation of clinical and pathological parameters. Although this has been a successful approach, some patients relapse and/or eventually develop resistance to treatment. This review is focused on recent studies on the possible biological and molecular mechanisms involved in both response and resistance to treatment in BC. Additionally, emerging treatments that seek to overcome resistance and reduce side effects are also described. A greater understanding of the mechanisms of action of treatments used in BC might contribute not only to the enhancement of our understanding of the mechanisms involved in the development of resistance but also to the optimization of the existing treatment regimens.

Keywords: breast cancer, endocrine therapy, chemotherapy, resistance, emerging treatments

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