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Research Progress on Regulating LncRNAs of Hepatocellular Carcinoma Stem Cells

Authors Zhang X, Zhu Y

Received 28 October 2020

Accepted for publication 21 January 2021

Published 10 February 2021 Volume 2021:14 Pages 917—927


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Prof. Dr. Nicola Silvestris

Xiaoli Zhang, Ying Zhu

Liver Disease Center of Integrated Traditional Chinese and Western Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People’s Republic of China

Correspondence: Ying Zhu Email

Abstract: Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies around the world. The self-renewal, proliferation, differentiation, and tumorigenic potential of liver cancer stem cells (LCSCs) may account for the high recurrence rate and the refractory feature of HCC. Despite extensive researches, the underlying regulatory mechanism of LCSCs has not been fully disclosed. Long nonprotein coding RNAs (lncRNAs) may exert an essential role in regulating various biological functions of LCSCs, such as maintaining the stemness of cancer stem cells (CSCs) and promoting tumor development. Therefore, it is highly critical to determine which lncRNAs can control LCSCs functions and understand how LCSCs are regulated by lncRNAs. Herein, we summarized lncRNAs and the main signaling pathways involved in the regulation of LCSCs found in recent years. Moreover, we shed light on the existence of the network system of lncRNAs and LCSCs, which may provide valuable clues on targeting LCSCs.

Keywords: hepatocellular carcinoma, HCC, liver cancer stem cells, LCSCs, long nonprotein coding RNAs, lncRNAs, signaling pathways, network

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