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Research Progress on Gestational Diabetes Mellitus and Endothelial Dysfunction Markers

Authors He Y, Wu N

Received 24 December 2020

Accepted for publication 15 February 2021

Published 3 March 2021 Volume 2021:14 Pages 983—990

DOI https://doi.org/10.2147/DMSO.S295737

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Konstantinos Tziomalos


Yujing He,1 Na Wu1,2

1Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, People’ s Republic of China; 2Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang, People’s Republic of China

Correspondence: Na Wu
Shengjing Hospital of China, 36 Sanhao Road, Heping District, Shenyang, Liaoning Province, 110004, People’s Republic of China
Tel +86 18940258445
Email [email protected]

Abstract: Gestational diabetes mellitus (GDM) is the onset or first recognition of diabetes during pregnancy in women with normal glucose metabolism or potentially impaired glucose tolerance before pregnancy. Studies have shown that vascular endothelial cells (VECs) are an important target organ of insulin, which is injured by multiple factors in the case of GDM, thereby leading to worsened insulin resistance (IR) and the further development of GDM. When VECs are abnormal, there will be changes in the content of a variety of cell markers, which may be helpful for the clinical prediction and diagnosis of GDM. This study attempted to investigate the mechanism and markers of VECs injury in GDM patients.

Keywords: gestational diabetes mellitus, endothelial cells, biomarkers

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