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Relative handgrip strength as a marker of metabolic syndrome: the Korea National Health and Nutrition Examination Survey (KNHANES) VI (2014–2015)

Authors Yi DW, Khang AR, Lee HW, Son SM, Kang YH

Received 28 February 2018

Accepted for publication 24 March 2018

Published 23 May 2018 Volume 2018:11 Pages 227—240

DOI https://doi.org/10.2147/DMSO.S166875

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Professor Ming-Hui Zou


Dongwon Yi,1,2 Ah Reum Khang,1,2 Hye Won Lee,1,2 Seok Man Son,1,2 Yang Ho Kang,1,2

1Division of Endocrinology and Metabolism, Department of Internal Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea; 2Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea

Purpose: Muscles play an important role in energy metabolism. Several studies have investigated the association between muscle mass and metabolic syndrome (MetS), reporting conflicting results. However, studies concerning the association between muscle strength and MetS are limited. We aimed to investigate the association between relative handgrip strength (HGS) and MetS in Korean adults.
Participants and methods: We analyzed data from 5,014 Korean adults aged ≥20 years (2,472 men and 2,542 women) who participated in the Korea National Health and Nutrition Examination Survey (KNHANES) VI (2014–2015).
Results: The increasing quartiles of relative HGS (defined as the sum of both hands’ HGS divided by body mass index) were inversely associated with the risk of MetS in both men and women (OR, 0.37; 95% CI, 0.30–0.45, vs OR, 0.19; 95% CI, 0.14–0.27, respectively) after multivariable adjustment for age, region of residence, smoking status, heavy alcohol consumption, regular exercise, family income, and education level. On multivariable logistic regression analyses, participants with the highest relative HGS had a significant decrease in relative risk of MetS, compared with those with the lowest relative HGS. The multivariable-adjusted ORs (with 95% CIs) for MetS in quartiles 1, 2, 3, and 4 were 1.00, 0.72 (0.55–0.94), 0.34 (0.26–0.46), and 0.22 (0.15–0.32) in men and 1.00, 0.50 (0.36–0.68), 0.26 (0.17–0.40), and 0.16 (0.09–0.27) in women, respectively.
Conclusion: Relative HGS showed a highly significant inverse association with the risk of MetS in Korean adults, and it can be a novel biomarker for assessing the risk of MetS.

Keywords: hand strength, metabolic syndrome X, adult, Korea, nutrition surveys

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